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KMID : 0624620090420020091
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BMB Reports
2009 Volume.42 No. 2 p.91 ~ p.95
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Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity
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Kim Bang-Hyun
Won Young-Suk
Kim Dae-Yong
Yoon Mi-Jung
Oh Goo-Taeg
Kim Bo-Ra
Kim Eun-Young
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Abstract
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Peroxisome proliferator-activated receptor α and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPARα-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E2-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E2-treated group, but interestingly not in PPARα-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E2-treated mice. These novel results suggest the possibility of signaling crosstalk between PPARα and E2, causing obesity in vivo.
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KEYWORD
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Estrogen, LPL, Obesity, PPARα, Signaling crosstalk
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